Cyclo‐oxygenase isoenzymes: physiological and pharmacological role

  title={Cyclo‐oxygenase isoenzymes: physiological and pharmacological role},
  author={P. Kam and A. S{\'e}e},
  • P. Kam, A. Sée
  • Published 2000
  • Medicine
  • Anaesthesia
  • Prostaglandins play important roles in inflammation and the maintenance of normal physiological function of several organ systems. Prostaglandin production requires the conversion of arachidonic acid to the intermediate prostaglandin H2 catalysed by the cyclo‐oxygenase (COX) enzyme. There are two isoforms of the COX enzyme, COX‐1 and COX‐2. These isoforms vary in their distribution and expression but are similar in size, substrate specificity and kinetics. Normal physiological functions are… CONTINUE READING
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