Cyclization of squalene from both termini: identification of an onoceroid synthase and enzymatic synthesis of ambrein.

@article{Ueda2013CyclizationOS,
  title={Cyclization of squalene from both termini: identification of an onoceroid synthase and enzymatic synthesis of ambrein.},
  author={Daijiro Ueda and Tsutomu Hoshino and Tsutomu Sato},
  journal={Journal of the American Chemical Society},
  year={2013},
  volume={135 49},
  pages={18335-8}
}
The onoceroids are triterpenoids biosynthesized from squalene or (3S)-2,3-oxidosqualene by cyclization from both termini. We recently revealed that tetraprenyl-β-curcumene cyclase from Bacillus megaterium (BmeTC) is a bifunctional triterpene/sesquarterpene cyclase that converts head-to-tail tetraprenyl-β-curcumene and tail-to-tail squalene into pentacyclic and bicyclic products, respectively, in vivo. Here, we reveal that BmeTC has an unprecedented catalytic function in cyclizing squalene from… CONTINUE READING

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