Cyclization cascades via N-amidyl radicals toward highly functionalized heterocyclic scaffolds.

  title={Cyclization cascades via N-amidyl radicals toward highly functionalized heterocyclic scaffolds.},
  author={Noelia Fuentes and Wangqing Kong and Luis Fern{\'a}ndez-S{\'a}nchez and Est{\'i}baliz Merino and Cristina Nevado},
  journal={Journal of the American Chemical Society},
  volume={137 2},
The addition of a variety of radicals to the double bond of N-(arylsulfonyl)acrylamides can trigger cyclization/aryl migration/desulfonylation cascades via amidyl radical intermediates 2. Herein, we demonstrate the synthetic utility of these intermediates in subsequent C-C and C-X bond-forming events to rapidly build up molecular complexity. First, we describe a regioselective one-pot synthesis of CF3-, SCF3-, Ph2(O)P-, and N3-containing indolo[2,1-a]isoquinolin-6(5H)-ones from N-[(2-ethynyl… 

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