Cyclins and the cyclin-kinase system--their potential roles in nephrology.


Our understanding of the cell-cycle mechanisms has progressively advanced in the past few years. Cyclins and cyclin-dependent kinases play major roles as positive cell-cycle regulatory proteins and CDK inhibitors; while the Kip family and INK4 family are negative regulatory proteins in mesangial cells and renal tubular cells. An understanding of the cell… (More)

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