Cyclins and cell cycle control in cancer and disease.

  title={Cyclins and cell cycle control in cancer and disease.},
  author={Mathew C. Casimiro and Marco Crosariol and Emanuele Loro and Zhiping Li and Richard G. Pestell},
  journal={Genes & cancer},
  volume={3 11-12},
Cyclin D1 overexpression is found in more than 50% of human breast cancers and causes mammary cancer in transgenic mice. Dysregulation of cyclin D1 gene expression or function contributes to the loss of normal cell cycle control during tumorigenesis. Recent studies have demonstrated that cyclin D1 conducts additional specific functions to regulate gene expression in the context of local chromatin, promote cellular migration, and promote chromosomal instability. It is anticipated that these… CONTINUE READING


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