Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth.

  title={Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth.},
  author={Jake A Kushner and Maria A Ciemerych and Ewa T. Sicinska and Lynn M. Wartschow and Monica Teta and Simon Y. Long and Piotr Sicinski and Morris F. White},
  journal={Molecular and cellular biology},
  volume={25 9},
Regulation of adult beta-cell mass in pancreatic islets is essential to preserve sufficient insulin secretion in order to appropriately regulate glucose homeostasis. In many tissues mitogens influence development by stimulating D-type cyclins (D1, D2, or D3) and activating cyclin-dependent kinases (CDK4 or CDK6), which results in progression through the G(1) phase of the cell cycle. Here we show that cyclins D2 and D1 are essential for normal postnatal islet growth. In adult murine islets basal… CONTINUE READING
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