Cycling of Dense Core Vesicles Involved in Somatic Exocytosis of Serotonin by Leech Neurons

@inproceedings{Trueta2012CyclingOD,
  title={Cycling of Dense Core Vesicles Involved in Somatic Exocytosis of Serotonin by Leech Neurons},
  author={Citlali Trueta and Damien P. Kuffler and Francisco F. De-Miguel},
  booktitle={Front. Physio.},
  year={2012}
}
We studied the cycling of dense core vesicles producing somatic exocytosis of serotonin. Our experiments were made using electron microscopy and vesicle staining with fluorescent dye FM1-43 in Retzius neurons of the leech, which secrete serotonin from clusters of dense core vesicles in a frequency-dependent manner. Electron micrographs of neurons at rest or after 1 Hz stimulation showed two pools of dense core vesicles. A perinuclear pool near Golgi apparatuses, from which vesicles apparently… CONTINUE READING

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