Cyclin is a component of maturation-promoting factor from Xenopus

@article{Gautier1990CyclinIA,
  title={Cyclin is a component of maturation-promoting factor from Xenopus},
  author={Jean Gautier and Jeremy Minshull and Manfred J. Lohka and Michael Glotzer and Timothy Hunt and James L. Maller},
  journal={Cell},
  year={1990},
  volume={60},
  pages={487-494}
}
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
Throughout oocyte maturation, and subsequently during the first mitotic cell cycle, the MAP kinase cascade and cyclin-B-Cdc2 kinase are associated with the control of cell cycle progression. Many
Phosphorylation of Xenopus cyclins B1 and B2 is not required for cell cycle transitions
TLDR
Results indicate that the phosphorylation of Xenopus B-type cyclins by cdc2 kinase or MAP kinase is not required for the hallmark functions of cyclin.
Characterization and physiological importance of a novel cell cycle regulated protein kinase in Xenopus laevis oocytes that phosphorylates cyclin B2.
TLDR
Using a synthetic peptide derived from cyclin B2 encompassing Ser53 (cyktide) as a substrate, cyk was shown to be activated during progesterone-induced maturation, with a peak of activity between 40 and 50% maturation and a sustained high cyk activity was observed in oscillating egg extracts.
Activation of the Xenopus cyclin degradation machinery by full-length cyclin A.
TLDR
The results presented here indicate thatcyclin A has not lost the ability to activate its own destruction and that cyclin A-mediated activation of the cyclin destruction pathway permitted destruction of cyclin B1 as well as cyclinA, indicating that there are not distinct Cyclin A and Cyclin B destruction pathways.
In vivo regulation of MPF in Xenopus oocytes.
TLDR
This work introduced cyclin into stage 4 (small) Xenopus oocytes and showed that it activates MPF in these cells, probably by interacting with endogenous p34cdc2 kinase.
Function and regulation of cdc25 protein phosphate through mitosis and meiosis.
TLDR
It is highly probable that a distinct protein kinase is involved as a trigger in cdc25 activation and the implication of raf kinase as a cDC25-specific activating kinase in human cells and Xenopus oocytes is discussed.
Synthesis of a 180 kDa protein is a molecular marker of Xenopus oocyte meiotic maturation.
  • R. Smith
  • Biology
    Cell differentiation and development : the official journal of the International Society of Developmental Biologists
  • 1990
Meiotic induction by Xenopus cyclin B is accelerated by coexpression with mosXe
TLDR
By preinjecting oocytes with a mosXe-specific antisense oligonucleotide, it is shown that GVBD induced by cyclin B does not require expression of the mosXE protein.
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References

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Purification of maturation-promoting factor, an intracellular regulator of early mitotic events.
TLDR
The highly purified preparations described here should help to identify the mechanism of action of maturation-promoting factor and to elucidate the role of protein kinases in the induction of metaphase.
The role of cyclin synthesis and degradation in the control of maturation promoting factor activity
We show that cyclin plays a pivotal role in the control of mitosis. A proteolysis-resistant mutant of cyclin prevents the inactivation of maturation promoting factor and the exit from mitosis both in
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