Cyclin expression and G2-phase delay after irradiation.

  title={Cyclin expression and G2-phase delay after irradiation.},
  author={Eric J. Bernhard and W. Gillies Mckenna and Ruth J. Muschel},
  journal={Radiation research},
  volume={138 1 Suppl},
Many studies have demonstrated the effect of oncogene transfection on the radiation sensitivity of primary rat embryo fibroblasts. Our results indicate that transformation by H-ras plus v-myc oncogenes confers radiation resistance to a much greater extent than transformation by either gene alone. We have further shown that the radioresistant phenotype is accompanied by a prolonged G2-phase delay. This is consistent with the hypothesis that the extent of this delay is an important determinant of… CONTINUE READING

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