Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism.

  title={Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism.},
  author={Philip Grant and Pushkar Sharma and Harish C. Pant},
  journal={European journal of biochemistry},
  volume={268 6},
Cyclin-dependent kinase 5 (Cdk5), a complex of Cdk5 and its activator p35 (Cdk5/p35), phosphorylates diverse substrates which have multifunctional roles in the nervous system. During development, it participates in neuronal differentiation, migration, axon outgrowth and synaptogenesis. Cdk5, acting together with other kinases, phosphorylates numerous KSPXK consensus motifs in diverse cytoskeletal protein target molecules, including neurofilaments, and microtubule associated proteins, tau and… CONTINUE READING


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