Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms

@article{Nguyen2001CyclindependentKP,
  title={Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms},
  author={Van Quy Nguyen and Carl Co and Joachim J Li},
  journal={Nature},
  year={2001},
  volume={411},
  pages={1068-1073}
}
The stable propagation of genetic information requires that the entire genome of an organism be faithfully replicated once and only once each cell cycle. In eukaryotes, this replication is initiated at hundreds to thousands of replication origins distributed over the genome, each of which must be prohibited from re-initiating DNA replication within every cell cycle. How cells prevent re-initiation has been a long-standing question in cell biology. In several eukaryotes, cyclin-dependent kinases… 
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