Cyclin-dependent kinases: a family portrait

  title={Cyclin-dependent kinases: a family portrait},
  author={Marcos Malumbres and Ed Harlow and Tim Hunt and Tony Hunter and Jill M. Lahti and Gerard Manning and David O. Morgan and Li-Huei Tsai and Debra J. Wolgemuth},
  journal={Nature Cell Biology},
To the Editor, Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits. Based on sequence similarity, the human genome contains 21 genes encoding CDKs and five additional genes encoding a more distant group of proteins known as CDK-like (CDKL) kinases. The current nomenclature for CDK proteins includes 11 classical CDKs (CDK1–11), two newly proposed family… 

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Mammalian cyclin-dependent kinases.

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  • Fang ShuShun Lv Jun Wu
  • Biology, Environmental Science
    Proceedings of the National Academy of Sciences
  • 2007
It is suggested that PFTK1 acts as a CDK that regulates cell cycle progression and cell proliferation and the tumor suppressor Rb is identified as a potential downstream substrate for the P FTK1/CCND3 complex.

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The protein kinase complement of the human genome is catalogued using public and proprietary genomic, complementary DNA, and expressed sequence tag sequences to provide a starting point for comprehensive analysis of protein phosphorylation in normal and disease states and a detailed view of the current state of human genome analysis through a focus on one large gene family.

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