Cyclin-dependent kinase pathways as targets for cancer treatment.

@article{Shapiro2006CyclindependentKP,
  title={Cyclin-dependent kinase pathways as targets for cancer treatment.},
  author={Geoffrey I. Shapiro},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 11},
  pages={
          1770-83
        }
}
Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA transcription. A variety of genetic and epigenetic events cause universal overactivity of the cell cycle cdks in human cancer, and their inhibition can lead to both cell cycle arrest and apoptosis. However, built-in redundancy may limit the effects of highly selective cdk inhibition. Cdk4/6 inhibition has been shown to induce potent G1 arrest in vitro and tumor regression in vivo; cdk2/1 inhibition has the… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 221 REFERENCES

Similar Papers

Loading similar papers…