Cyclin-dependent kinase inhibitors as marketed anticancer drugs: where are we now? A short survey.

@article{Mariaule2014CyclindependentKI,
  title={Cyclin-dependent kinase inhibitors as marketed anticancer drugs: where are we now? A short survey.},
  author={Ga{\"e}lle Mariaule and Philippe Belmont},
  journal={Molecules},
  year={2014},
  volume={19 9},
  pages={14366-82}
}
In the early 2000s, the anticancer drug imatinib (Glivec®) appeared on the market, exhibiting a new mode of action by selective kinase inhibition. Consequently, kinases became a validated therapeutic target, paving the way for further developments. Although these kinases have been thoroughly studied, none of the compounds commercialized since then target cyclin-dependent kinases (CDKs). Following a recent and detailed review on the subject by Galons et al., we concentrate our attention on an… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 63 references

LEE011 CDK Inhibitor Showing Early Promise in Drug-Resistant Cancers

S. Kurt
Oncol. Times 2014, • 2014
View 10 Excerpts
Highly Influenced

Targeting Protein Kinases for Cancer Therapy

D. J. Matthews, M. E. Gerritsen
2010
View 8 Excerpts
Highly Influenced

Cyclin-dependent kinase inhibitors closer to market launch?

Expert opinion on therapeutic patents • 2013
View 4 Excerpts
Highly Influenced

Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2010
View 3 Excerpts
Highly Influenced

A phase II study of milciclib (PHA-848125AC) in patients with thymic carcinoma

B. Besse, M. C. Garassino, +7 authors C Davite
In Proceedings of the American Society of Clinical Oncology Conference, • 2014
View 2 Excerpts

Blockbuster dreams for Pfizer's CDK inhibitor

Nature Biotechnology • 2013
View 1 Excerpt

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