Cyclin-dependent kinase inhibitors as anticancer drugs.

  title={Cyclin-dependent kinase inhibitors as anticancer drugs.},
  author={Vladim{\'i}r Kry{\vs}tof and Stjepan Uldrijan},
  journal={Current drug targets},
  volume={11 3},
Poor therapeutic outcomes and serious side effects, together with acquired resistance to multiple drugs, are common problems of current cancer therapies. Therefore, there is an urgent need for new cancer-targeted drugs, which has led (inter alia) to the development of molecules that can specifically inhibit cyclin-dependent kinases (CDKs). In addition to their cell cycle regulatory functions, CDKs, especially CDK7 and CDK9, play important roles in the regulation of RNA polymerase II-mediated… CONTINUE READING

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