Cyclin-dependent kinase inhibitors and the treatment of gastrointestinal cancers.

@article{Mikhail2015CyclindependentKI,
  title={Cyclin-dependent kinase inhibitors and the treatment of gastrointestinal cancers.},
  author={Sameh E Mikhail and Chris Albanese and Michael J Pishvaian},
  journal={The American journal of pathology},
  year={2015},
  volume={185 5},
  pages={1185-97}
}
The cell cycle is a highly conserved and tightly regulated biological system that controls cellular proliferation and differentiation. The cell cycle regulatory proteins, which include the cyclins, the cyclin-dependent kinases (CDKs), and the CDK inhibitors, are critical for the proper temporal and spatial regulation of cellular proliferation. Conversely, alterations in cell cycle regulatory proteins, leading to the loss of normal cell-cycle control, are a hallmark of many cancers, including… CONTINUE READING