Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons.

@article{Park1997CyclinDK,
  title={Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons.},
  author={David S. Park and Beth Levine and Giovanna Ferrari and Lloyd A Greene},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1997},
  volume={17 23},
  pages={8975-83}
}
Neuronal apoptosis plays a critical role in both normal development and disease. However, the precise molecular events controlling neuronal apoptosis are not well understood. Previously, we hypothesized that cell cycle regulatory molecules function in controlling the apoptotic pathways of trophic factor-deprived neurons. To test this hypothesis, we used the RNA alphavirus Sindbis to express three known cyclin dependent kinase inhibitors (CKIs), p16(ink4), p21(waf/cip), and p27(kip1), and… CONTINUE READING

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Nedd 2 is required for apoptosis after trophic support withdrawal , but not superoxide dismutase ( SOD 1 ) downregulation , in sympathetic neurons and PC 12 cells

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