Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents.

@article{Leitch2009CyclindependentKI,
  title={Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents.},
  author={Andrew E. Leitch and Christopher Haslett and Adriano G Rossi},
  journal={British journal of pharmacology},
  year={2009},
  volume={158 4},
  pages={1004-16}
}
The cyclin-dependent kinase inhibitor (CDKi) drugs such as R-roscovitine have emerged as potential anti-inflammatory, pharmacological agents that can influence the resolution of inflammation. Usually, once an inciting inflammatory stimulus has been eliminated, resolution proceeds by prompt, safe removal of dominant inflammatory cells. This is accomplished by programmed cell death (apoptosis) of prominent effector, inflammatory cells typified by the neutrophil. Apoptosis of neutrophils ensures… CONTINUE READING