Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells.

@article{Li2007CyclindependentKI,
  title={Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells.},
  author={Yan Li and Kazuhiro Tanaka and Xin Li and Takamitsu Okada and Tomoyuki Nakamura and Minoru Takasaki and Shunsaku Yamamoto and Yoshinao Oda and Masazumi Tsuneyoshi and Yukihide Iwamoto},
  journal={International journal of cancer},
  year={2007},
  volume={121 6},
  pages={1212-8}
}
Multimodal therapies play important roles in the treatment of osteosarcoma (OS) and Ewing's family of tumors (EFTs), two most frequent malignant bone tumors. Although the clinical outcome of primary OS and EFTs is greatly improved, the relapsed cases often are associated with multidrug resistance of the tumors and the prognosis of these patients is still poor. Flavopiridol, a pan cyclin-dependent kinase (CDK) inhibitor is a novel antitumor agent that can induce cell cycle arrest and apoptosis… CONTINUE READING
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