Cyclin-dependent kinase activation and S-phase induction of the cyclin B1 gene are linked through the CCAAT elements.

@article{Katula1997CyclindependentKA,
  title={Cyclin-dependent kinase activation and S-phase induction of the cyclin B1 gene are linked through the CCAAT elements.},
  author={Karen S Katula and Kenneth L. Wright and Hubert Paul and Deborah R. Surman and Faison Nuckolls and Jesse W. Smith and Jenny Pan-Yun Ting and John Yates and John P. Cogswell},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1997},
  volume={8 7},
  pages={811-20}
}
Control of cell proliferation is dependent on the regulated expression of the cyclin genes. Induction of cyclin B1 gene expression in S phase has been shown to require sequences within the first 90 bp of the proximal promoter region. In this study, we defined the cell cycle regulatory elements within this region and explored the mechanism by which the cyclin B1 gene is activated. A CDE-like element that is important in S-phase regulation of other genes was not required for correct cell cycle… CONTINUE READING