Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells

@inproceedings{Lindqvist2015CyclindependentK5,
  title={Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells},
  author={Julia Lindqvist and Susumu Y. Imanishi and Elin Torvaldson and Marjo Malinen and Mika Remes and Fanny {\"O}rn and Jorma J. Palvimo and John E. Eriksson and Thomas Michael Magin},
  booktitle={Molecular biology of the cell},
  year={2015}
}
Contrary to cell cycle-associated cyclin-dependent kinases, CDK5 is best known for its regulation of signaling processes in differentiated cells and its destructive activation in Alzheimer's disease. Recently, CDK5 has been implicated in a number of different cancers, but how it is able to stimulate cancer-related signaling pathways remains enigmatic. Our goal was to study the cancer-promoting mechanisms of CDK5 in prostate cancer. We observed that CDK5 is necessary for proliferation of several… CONTINUE READING
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