Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy.

@article{Bhandari2015CyclindependentK5,
  title={Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy.},
  author={Deepali Bhandari and Inmaculada L{\'o}pez-S{\'a}nchez and Andrew To and I-Chung Lo and Nicolas Aznar and Anthony Leyme and Vijay R. Gupta and Ingrid R. Niesman and Adam L Maddox and Mikel Garcia-Marcos and Marilyn Gist Farquhar and Pradipta Ghosh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 35},
  pages={E4874-83}
}
Signals propagated by receptor tyrosine kinases (RTKs) can drive cell migration and proliferation, two cellular processes that do not occur simultaneously--a phenomenon called "migration-proliferation dichotomy." We previously showed that epidermal growth factor (EGF) signaling is skewed to favor migration over proliferation via noncanonical transactivation… CONTINUE READING