Cyclin-dependent kinase 5 (CDK5) and neuronal cell death

@article{Weishaupt2003CyclindependentK5,
  title={Cyclin-dependent kinase 5 (CDK5) and neuronal cell death},
  author={Jochen H Weishaupt and Clemens Neusch and Mathias B{\"a}hr},
  journal={Cell and Tissue Research},
  year={2003},
  volume={312},
  pages={1-8}
}
Many neurological disorders like Parkinson's and Alzheimer's disease, amyotrophic lateral sclerosis (ALS) or stroke have in common a definite loss of CNS neurons due to apoptotic or necrotic neuronal cell death. Previous studies suggested that proapoptotic stimuli may trigger an abortive and, therefore, eventually fatal cell cycle reentry in postmitotic neurons. Neuroprotective effects of small molecule inhibitors of cyclin-dependent kinases (CDKs), which are key regulators of cell cycle… CONTINUE READING

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