Cyclin-dependent kinase 4 is a novel target in micoRNA-195-mediated cell cycle arrest in bladder cancer cells.

@article{Lin2012CyclindependentK4,
  title={Cyclin-dependent kinase 4 is a novel target in micoRNA-195-mediated cell cycle arrest in bladder cancer cells.},
  author={Yiwei Lin and Jiayi Wu and Hong Chen and Ye-qing Mao and Yunfu Liu and Qiqi Mao and Kong-he Yang and Xiangyi Zheng and Liping Xie},
  journal={FEBS letters},
  year={2012},
  volume={586 4},
  pages={
          442-7
        }
}
miRNAs are a class of small-noncoding RNAs capable of negatively regulating gene expression. Here, we found that miR-195 is down-regulated in human bladder cancer tissue versus normal adjacent tissue. To better characterize the role of miR-195 in bladder cancer, we conducted gain of function analysis by transfecting bladder cancer cell line T24 with chemically synthesized miR-195 mimic. We identified CDK4, an early G1 cell cycle regulator, as a novel target of miR-195. Selective over-expression… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 49 CITATIONS

MicroRNA-195: a review of its role in cancers

  • OncoTargets and therapy
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND

Coactivator-associated arginine methyltransferase 1 promotes cell growth and is targeted by microRNA-195-5p in human colorectal cancer.

  • Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • 2017

Evaluation of MicroRNA-99a and MicroRNA-205 Expression Levels in Bladder Cancer

  • International journal of molecular and cellular medicine
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND