Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly

  title={Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly},
  author={Wesley A Braden and A. Kathleen McClendon and Erik S. Knudsen},
Cyclin-dependent kinases (CDKs) are important in regulating cell cycle transitions, particularly in coordinating DNA replication. Although the role of CDK2 activity on the replication apparatus has been extensively studied, the role of CDK4/6 in DNA replication control is less understood. Through targeted inhibition of CDK4/6 activity, we demonstrate that CDK4/6 kinase activity promotes cdc6 and cdt1 expression, and pre-replication complex (pre-RC) assembly in cycling cells. Conversely, CDK2… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 60 references

The chromosome replication cycle.

Journal of cell science • 2002
View 5 Excerpts
Highly Influenced

Finishing mitosis, one step at a time

Nature Reviews Molecular Cell Biology • 2007
View 1 Excerpt

Kinase-independent function of cyclin E.

Molecular cell • 2007
View 1 Excerpt

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