Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin.

  title={Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin.},
  author={Sang Il Kim and Chun Shik Park and Mi Su Lee and Min Seong Kwon and Eek-Hoon Jho and Woo Keun Song},
  journal={Biochemical and biophysical research communications},
  volume={317 2},
Axin, a negative regulator of Wnt, forms a complex with glycogen synthase kinase 3beta, beta-catenin, and adenomatous polyposis coli and promotes GSK3beta-dependent phosphorylation of beta-catenin, thereby stimulating degradation of the beta-catenin. An essential step in that process is the phosphorylation of Axin. Examination of Axin's amino acid sequence revealed it to contain six arginine-X-leucine (RXL) sequences, the cyclin-dependent kinase 2 (CDK2) binding motif, and 10 CDK2 consensus… CONTINUE READING

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