Cyclin-dependent kinase 2 nucleocytoplasmic translocation is regulated by extracellular regulated kinase.

@article{Keenan2001CyclindependentK2,
  title={Cyclin-dependent kinase 2 nucleocytoplasmic translocation is regulated by extracellular regulated kinase.},
  author={Susan M Keenan and Clifford J. Bellone and Joseph J. Baldassare},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 25},
  pages={22404-9}
}
Activation of cyclin-dependent kinase 2 (CDK2)-cyclin E in the late G(1) phase of the cell cycle is important for transit into S phase. In Chinese hamster embryonic fibroblasts (IIC9) phosphatidylinositol 3-kinase and ERK regulate alpha-thrombin-induced G(1) transit by their effects on cyclin D1 protein accumulation (Phillips-Mason, P. J., Raben, D. M., and Baldassare, J. J. (2000) J. Biol. Chem. 275, 18046-18053). Here, we show that ERK also affects CDK2-cyclin E activation by regulating the… CONTINUE READING

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