Cyclin Ubiquitination: The destructive end of mitosis

  title={Cyclin Ubiquitination: The destructive end of mitosis},
  author={Andrew Murray},
The problem of how cells make rapid but orderly transitions between different phases of the cell cycle has fascinated biologists since they first observed mitosis late in the nineteenth century. Physiological experiments first suggested that progress through particular phases of the cell cycle might depend on the accumulation of critical "periodic" proteins, and the discovery that cyclin B accumulates during interphase of embryonic cell cycles later provided a molecular candidate for the… CONTINUE READING
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