Cyclin T2 is essential for mouse embryogenesis.

  title={Cyclin T2 is essential for mouse embryogenesis.},
  author={Jiř{\'i} Kohoutek and Qintong Li and Dalibor Bla{\vz}ek and Zeping Luo and Huimin Jiang and Boris Matija Peterlin},
  journal={Molecular and cellular biology},
  volume={29 12},
The positive transcription elongation factor b (P-TEFb) is essential for the elongation of transcription and cotranscriptional processing by RNA polymerase II. In mammals, it contains predominantly the C-type cyclin cyclin T1 (CycT1) or CycT2 and cyclin-dependent kinase 9 (Cdk9). To determine if these cyclins have redundant functions or affect distinct sets… CONTINUE READING