Cyclin T1 expression is regulated by multiple signaling pathways and mechanisms during activation of human peripheral blood lymphocytes.

@article{Marshall2005CyclinTE,
  title={Cyclin T1 expression is regulated by multiple signaling pathways and mechanisms during activation of human peripheral blood lymphocytes.},
  author={Ren{\'e}e M. Marshall and Dominic M Salerno and Judit Garriga and Xavier Gra{\~n}a},
  journal={Journal of immunology},
  year={2005},
  volume={175 10},
  pages={6402-11}
}
Stimulation of primary human T lymphocytes results in up-regulation of cyclin T1 expression, which correlates with phosphorylation of the C-terminal domain of RNA polymerase II (RNAP II). Up-regulation of cyclin T1 and concomitant stabilization of cyclin-dependent kinase 9 (CDK9) may facilitate productive replication of HIV in activated T cells. We report… CONTINUE READING