Cyclin H is targeted to the nucleus by C-terminal nuclear localization sequences

  title={Cyclin H is targeted to the nucleus by C-terminal nuclear localization sequences},
  author={Andrea Krempler and Sabine Kartarius and J{\"u}rgen G{\"u}nther and Mathias Montenarh},
  journal={Cellular and Molecular Life Sciences},
Cdk-activating kinase (CAK) is a trimeric complex consisting of cdk7, cyclin H, and MAT1, which activates the cell-cycle-regulating cdks through T loop phosphorylation. In addition, other substrates of the CAK complex have been identified when CAK is assembled with the TFIIH core proteins, thereby regulating transcription and nucleotide excision repair. Little is known about the regulation of the CAK complex through cyclin H. In this study we further analyzed cyclin H regulation and identified… CONTINUE READING
7 Citations
50 References
Similar Papers


Publications citing this paper.
Showing 1-7 of 7 extracted citations


Publications referenced by this paper.
Showing 1-10 of 50 references

Mutation of a CK 2 phosphorylation site in cdc 25 C impairs im - portin a / b binding and results in cytoplasmic retention

  • L. SchwindlingS., A. Noll, M. Montenarh, C Götz
  • 2004

Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis

  • D. MooreJ., S. Kornbluth, T Hunt
  • Mol . Biol . Cell
  • 2002

T - loop phosphorylation stabilizes the CDK 7 - cyclin HMAT 1 complex in vivo and regulates its CTD kinase activity

  • S. Larochelle, J. Chen, R. Knights, J. Pandur, P. Morcillo
  • EMBO J .
  • 2001

Similar Papers

Loading similar papers…