Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery

  title={Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery},
  author={Shinya H. Kimura and Masahito Ikawa and Akihiko Ito and Masaru Okabe and Hiroshi Nojima},
Cyclin G1 is one of the target genes of the transcription factor p53, and is induced in a p53-dependent manner in response to DNA damage. Although cyclin G1 has been implicated in a range of biological phenomena, its precise function remains unclear. Here we present an analysis of the physiological role of cyclin G1 using mice homozygous for a targeted disruption of the cyclin G1 gene. In order to clarify the role of cyclin G1 in the p53 pathway, downstream events such as apoptosis, cell growth… CONTINUE READING
Highly Cited
This paper has 108 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 61 extracted citations

The role of Cyclin G1 in cellular proliferation and apoptosis of human epithelial ovarian cancer

Journal of Molecular Histology • 2015
View 4 Excerpts
Highly Influenced

Genome-wide gene expression analysis in mouse embryonic stem cells.

The International journal of developmental biology • 2011
View 5 Excerpts
Highly Influenced

Estrogen and progesterone promote breast cancer cell proliferation by inducing cyclin G1 expression

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas • 2018
View 1 Excerpt

CyclinG1 Amplification Enhances Aurora Kinase Inhibitor-Induced Polyploid Resistance and Inhibition of Bcl-2 Pathway Reverses the Resistance.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2017

108 Citations

Citations per Year
Semantic Scholar estimates that this publication has 108 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-7 of 7 references

Cell Mol

W. Deppert
Life Sci., 55, 12 ± 27. Jayaraman L and Prives C. (1999). Cell Mol. Life Sci., 55, • 1999


N. Wake
Biophys. Res. Commun., • 1998


HU Smith ML. Kontny, R Bortnick, AJ. Fornace
Cell Res., 230, 61 ± 68. • 1997


M Mulheisen, JW Hell, AF. Wahl
Biol. • 1997


Wahl AF.
Biol. Chem., 271, 6050 ± 6061. Hunter T. (1991). Semin. Cell Biol., 2, 213 ± 222. Ikawa M, Wada I, Kominami K, Watanabe D, Toshimori K, • 1996

Nature, 377, 552 ± 557

Hannon GJ.
Choisy Rossi C, Reisdorf P and Yonish Rouach E. (1998). • 1995

Teratocarcinoma and Embryonic Stem

EJ Robertson