Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways.

@article{Zhao2003CyclinGH,
  title={Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways.},
  author={Lili Zhao and Tina L Samuels and Sarah Winckler and Chandrashekhar K Korgaonkar and Van S. Tompkins and Mary C Horne and Dawn E. Quelle},
  journal={Molecular cancer research : MCR},
  year={2003},
  volume={1 3},
  pages={195-206}
}
Cyclin G1 is a p53-responsive gene that is induced in alternative reading frame (ARF)-arrested cells, yet its role in growth control is unclear. We tested its effects on growth and involvement in the ARF-Mdm2-p53 tumor suppressor pathway. We show that cyclin G1 interacts with ARF, Mdm2, and p53 in vitro and in vivo. At high levels, cyclin G1 induces a G(1)-phase arrest in mammalian cells that coincides with p53 activation. Conversely, lower levels of cyclin G1 lack intrinsic growth inhibitory… CONTINUE READING

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5M.C. Horne, unpublished data

  • A. F. Wahls
  • Molecular Cancer Research 205 on June
  • 2003
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