Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study.

@article{Dumitriu2011CyclinGassociatedKM,
  title={Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study.},
  author={Alexandra Dumitriu and Chris D Pacheco and Jemma B. Wilk and Katherine E. Strathearn and Jeanne Latourelle and Stefano Goldwurm and Gianni Pezzoli and Jean-Christophe Rochet and Susan Lindquist and Richard H. Myers},
  journal={Human molecular genetics},
  year={2011},
  volume={20 8},
  pages={1478-87}
}
Although family history is a well-established risk factor for Parkinson's disease (PD), fewer than 5% of PD cases can be attributed to known genetic mutations. The etiology for the remainder of PD cases is unclear; however, neuronal accumulation of the protein α-synuclein is common to nearly all patients, implicating pathways that influence α-synuclein in PD pathogenesis. We report a genome-wide significant association (P = 3.97 × 10(-8)) between a polymorphism, rs1564282, in the cyclin-G… CONTINUE READING