Cyclin G-associated kinase: a novel androgen receptor-interacting transcriptional coactivator that is overexpressed in hormone refractory prostate cancer.

@article{Ray2006CyclinGK,
  title={Cyclin G-associated kinase: a novel androgen receptor-interacting transcriptional coactivator that is overexpressed in hormone refractory prostate cancer.},
  author={M Roshni Ray and Latif A. Wafa and Helen Cheng and Robert Snoek and Ladan Fazli and Martin E. Gleave and Paul S. Rennie},
  journal={International journal of cancer},
  year={2006},
  volume={118 5},
  pages={1108-19}
}
The androgen receptor (AR), a steroid receptor family member, is a ligand-dependent transcription factor that has an integral role in normal prostate development. Alterations in AR-mediated activity can result in abnormal gene expression, dysregulated cell growth and prostate cancer. Coregulator proteins that interact with AR to influence activity and specificity of the AR-response may also have an important role in prostate cancer progression. Since the NH(2)-terminal domain (NTD) of AR… CONTINUE READING

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