Cyclin F Is Degraded during G2-M by Mechanisms Fundamentally Different from Other Cyclins*

@article{Fung2002CyclinFI,
  title={Cyclin F Is Degraded during G2-M by Mechanisms Fundamentally Different from Other Cyclins*},
  author={T. Fung and W. Y. Siu and C. Yam and A. Lau and R. Poon},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={35140 - 35149}
}
Cyclin F, a cyclin that can form SCF complexes and bind to cyclin B, oscillates in the cell cycle with a pattern similar to cyclin A and cyclin B. Ectopic expression of cyclin F arrests the cell cycle in G2/M. How the level of cyclin F is regulated during the cell cycle is completely obscure. Here we show that, similar to cyclin A, cyclin F is degraded when the spindle assembly checkpoint is activated and accumulates when the DNA damage checkpoint is activated. Cyclin F is a very unstable… Expand
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