Cyclin E1 Inhibition can Overcome Sorafenib Resistance in Hepatocellular Carcinoma Cells Through Mcl-1 Suppression.

@article{Hsu2016CyclinEI,
  title={Cyclin E1 Inhibition can Overcome Sorafenib Resistance in Hepatocellular Carcinoma Cells Through Mcl-1 Suppression.},
  author={C Hsu and L I Lin and Yu-Che Cheng and Zi-Rui Feng and Y Shao and Ann-lii Cheng and D Ou},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2016},
  volume={22 10},
  pages={
          2555-64
        }
}
PURPOSE To clarify the effects of cyclin E1 suppression on antitumor efficacy of sorafenib in hepatocellular carcinoma cells and to explore the potential of combining sorafenib with cyclin-dependent kinase (CDK) inhibition in therapy. EXPERIMENTAL DESIGN The effects of cyclin E1 suppression on sorafenib-induced apoptosis were tested in both sorafenib… CONTINUE READING