Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer.

@article{MllerTidow2001CyclinEI,
  title={Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer.},
  author={Carsten M{\"u}ller-Tidow and Ralf Metzger and K K{\"u}gler and Sven Diederichs and Gregory E. Idos and Melanie E Thomas and Barbara Dockhorn-Dworniczak and Paul Magnus Schneider and H Phillip Koeffler and Wolfgang E. Berdel and Hubert Serve},
  journal={Cancer research},
  year={2001},
  volume={61 2},
  pages={647-53}
}
Progression through G1-S transition and S phase of the cell cycle is mediated by cyclin-dependent kinase 2 (cdk2), which interacts with several cyclins. Two of these, cyclin E and cyclin A2 (also known as cyclin A), are overexpressed in many cancers. Cyclin E2 and cyclin A1 are recently discovered cdk2-interacting cyclins that are found in malignant tumor cell lines and in acute myeloid leukemia, respectively. Expression and prognostic role of these cyclins in solid tumors is unknown. Here, we… CONTINUE READING

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