Cyclin E and its low molecular weight forms in human cancer and as targets for cancer therapy.

@article{Akli2003CyclinEA,
  title={Cyclin E and its low molecular weight forms in human cancer and as targets for cancer therapy.},
  author={Said Akli and Khandan Keyomarsi},
  journal={Cancer biology & therapy},
  year={2003},
  volume={2 4 Suppl 1},
  pages={S38-47}
}
The progression of a cell through the cell cycle is promoted by cyclin dependent kinases (CDKs), which are positively regulated by cyclins and negatively regulated by CDK inhibitors. D type cyclins interact with CDK4 and CDK6 to drive the progression of a cell through early/mid-G(1)in response to mitogen stimulation. The association of cyclin E with CDK2 forms an active complex in late G(1) that directs entry into S-phase. S-phase progression is directed by the cyclin A/CDK2 complex, and the… CONTINUE READING

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