Cyclin-Dependent Kinases and S Phase Control in Mammalian Cells

@article{Woo2003CyclinDependentKA,
  title={Cyclin-Dependent Kinases and S Phase Control in Mammalian Cells},
  author={Richard A. Woo and R. Poon},
  journal={Cell Cycle},
  year={2003},
  volume={2},
  pages={315 - 323}
}
Mammalian DNA replication is an elegantly choreographed process in which multiple components are assembled at the origins to form the prereplication complex. Formation and activation of the prereplication complex requires coordinate actions of G1 and S phase cyclin-dependent kinases. Cyclin E-CDK2 and cyclin A-CDK2, together with DBF4-CDC7, phosphorylate several components of the prereplication complex and replication machinery. In this review, we summarize the current understanding of the… Expand
The role of cyclin E in cell cycle regulation and genomic instability
G1 phase: components, conundrums, context.
The Cell Cycle
Deregulation of cyclin E in human cells interferes with prereplication complex assembly
...
1
2
3
4
5
...