Cyclin-Dependent Kinase Activity Controls the Onset of the HCMV Lytic Cycle

@inproceedings{Zydek2010CyclinDependentKA,
  title={Cyclin-Dependent Kinase Activity Controls the Onset of the HCMV Lytic Cycle},
  author={Martin Zydek and Christian Hagemeier and L{\"u}der Wiebusch},
  booktitle={PLoS pathogens},
  year={2010}
}
The onset of human cytomegalovirus (HCMV) lytic infection is strictly synchronized with the host cell cycle. Infected G0/G1 cells support viral immediate early (IE) gene expression and proceed to the G1/S boundary where they finally arrest. In contrast, S/G2 cells can be infected but effectively block IE gene expression and this inhibition is not relieved until host cells have divided and reentered G1. During latent infection IE gene expression is also inhibited, and for reactivation to occur… CONTINUE READING

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