Cyclin-Dependent Kinase 6 Phosphorylates NF-κB P65 at Serine 536 and Contributes to the Regulation of Inflammatory Gene Expression

@inproceedings{Buss2012CyclinDependentK6,
  title={Cyclin-Dependent Kinase 6 Phosphorylates NF-κB P65 at Serine 536 and Contributes to the Regulation of Inflammatory Gene Expression},
  author={Holger Buss and Katja Handschick and Nadine Jurrmann and Pirita Pekkonen and Knut Beuerlein and Helmut M{\"u}ller and Robin Wait and Jeremy Saklatvala and P{\"a}ivi M Ojala and Michael Schmitz and Michael Naumann and Michael Kracht},
  booktitle={PloS one},
  year={2012}
}
Nuclear factor kappa-B (NF-κB) activates multiple genes with overlapping roles in cell proliferation, inflammation and cancer. Using an unbiased approach we identified human CDK6 as a novel kinase phosphorylating NF-κB p65 at serine 536. Purified and reconstituted CDK6/cyclin complexes phosphorylated p65 in vitro and in transfected cells. The physiological role of CDK6 for basal as well as cytokine-induced p65 phosphorylation or NF-κB activation was revealed upon RNAi-mediated suppression of… CONTINUE READING

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