Cyclin D3 gene amplification in bladder carcinoma in situ

  title={Cyclin D3 gene amplification in bladder carcinoma in situ},
  author={Antonio Lopez-Beltran and Jos{\'e} Luis Ord{\'o}{\~n}ez and Ana P. Otero and Ana Blanca and Vicky Sevillano and Marta S{\'a}nchez-Carbayo and Elisa G{\'a}lvez Mu{\~n}oz and Liang Cheng and Rodolfo Montironi and Enrique de {\'A}lava},
  journal={Virchows Archiv},
Carcinoma in situ (CIS) is a non-papillary high-grade, potentially aggressive, and unpredictable manifestation of bladder urothelial carcinoma. The aim of this study was to assess patterns of Cyclin D3 gene amplification in Bacillus Calmette-Guerin (BCG)-treated CIS and correlate gene status with recurrence-free and progression-free survival. A sequential cohort series of 28 primary (isolated) or secondary (concomitant) bladder CIS samples in which there was enough tissue material to assess… CONTINUE READING