Cyclin D2 induces proliferation of cardiac myocytes and represses hypertrophy.

Abstract

The myocytes of the adult mammalian heart are considered unable to divide. Instead, mitogens induce cardiomyocyte hypertrophy. We have investigated the effect of adenoviral overexpression of cyclin D2 on myocyte proliferation and morphology. Cardiomyocytes in culture were identified by established markers. Cyclin D2 induced DNA synthesis and proliferation… (More)

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@article{Busk2005CyclinDI, title={Cyclin D2 induces proliferation of cardiac myocytes and represses hypertrophy.}, author={Peter K. Busk and Rebecca Hinrichsen and Jirina Bartkova and Ane H{\aa}kansson Hansen and Tue E H Christoffersen and Jiri Bartek and Stig Hauns\o}, journal={Experimental cell research}, year={2005}, volume={304 1}, pages={149-61} }