Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells.

@article{Becker2010CyclinDA,
  title={Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells.},
  author={Klaus A. Becker and Prachi N Ghule and Jane B Lian and Janet L Stein and Andre J van Wijnen and Gary S Stein},
  journal={Journal of cellular physiology},
  year={2010},
  volume={222 2},
  pages={456-64}
}
Self-renewal of pluripotent human embryonic stem (hES) cells utilizes an abbreviated cell cycle that bypasses E2F/pRB-dependent growth control. We investigated whether self-renewal is alternatively regulated by cyclin/CDK phosphorylation of the p220(NPAT)/HiNF-P complex to activate histone gene expression at the G1/S phase transition. We show that cyclin D2… CONTINUE READING