Cyclin D1 protein and CCND1 gene expression in colorectal cancer.

  title={Cyclin D1 protein and CCND1 gene expression in colorectal cancer.},
  author={Ewa Izabela Balcerczak and Grażyna Pasz-Walczak and Pawelł Kumor and Mariusz Panczyk and Radzislaw Kordek and Rafal F Wierzbicki and Marek Mirowski},
  journal={European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology},
  volume={31 7},
AIMS To report the expression of cyclin D1 protein and its gene in a series of colorectal adenocarcinoma. METHODS One hundred and eleven specimens of colorectal carcinomas and adjacent normal colorectal mucosa were investigated by staining with a monoclonal antibody against cyclin D1 and by RT-PCR. RESULTS Expression of CCND1 gene was found in 54 out of 111 cases of colorectal cancers, while in normal mucosa the expression of this gene was not observed. Cyclin D1 protein expression was… CONTINUE READING