Cyclin D1 positive diffuse large B-cell lymphoma is a post-germinal center-type lymphoma without alterations in the CCND1 gene locus.

@article{VelaChvez2011CyclinDP,
  title={Cyclin D1 positive diffuse large B-cell lymphoma is a post-germinal center-type lymphoma without alterations in the CCND1 gene locus.},
  author={Teresa Vela-Ch{\'a}vez and Patrick Adam and Marcus Kremer and Karin Bink and Christopher M. Bacon and Geetha S. Menon and Robert E. Scully and Falko Fend and Elaine S. Jaffe and Leticia Quintanilla-Martinez},
  journal={Leukemia & lymphoma},
  year={2011},
  volume={52 3},
  pages={
          458-66
        }
}
The aims of this study were to analyze the incidence and morphology of cyclin D1+ DLBCL and cases of Richter transformation (RT), and to elucidate possible molecular mechanisms of cyclin D1 overexpression. Seventy-two cases of de novo DLBCL and 12 cases of RT were included in this study. Cyclin D1 positivity was found in 10/66 (15%) cases of unselected de novo DLBCL and in 2/11 (18%) cases of RT. Seven independently identified cases of cyclin D1+ DLBCL, including one RT, were added to the study… CONTINUE READING
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