Cyclin D1 overexpression in hepatocellular carcinoma.

  title={Cyclin D1 overexpression in hepatocellular carcinoma.},
  author={M Joo and Yun Kyung Kang and Mee-Ran Kim and H K Lee and Ja June Jang},
  volume={21 2},
BACKGROUND/AIMS Cyclin D1 gene amplification and cyclin D1 protein overexpression have been reported in various human tumors, including hepatocellular carcinoma (HCC). However, their significance is still controversial. In the present study, we examined the expression of cyclin D1 and its relationships to p53 and Ki-67 in HCCs. METHODS The expression and topological distribution of cyclin D1, p53 and Ki-67 in 50 cases of HCC were examined immunohistochemically, and the relationship between… CONTINUE READING

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