Cyclin D1 overexpression combined with N-nitrosomethylbenzylamine increases dysplasia and cellular proliferation in murine esophageal squamous epithelium

@article{Jenkins1999CyclinDO,
  title={Cyclin D1 overexpression combined with N-nitrosomethylbenzylamine increases dysplasia and cellular proliferation in murine esophageal squamous epithelium},
  author={Timothy D. Jenkins and Annegret Mueller and Robert Odze and Aliakbar Shahsafaei and Lawrence R. Zukerberg and Ralph Kent and Gary David Stoner and Anil K Rustgi},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={59-66}
}
We previosuly described the oral-esophageal tissue-specific expression of cyclin D1 with the Epstein – Barr virus ED-L2 promoter in transgenic mice, and resulting dysplasia. Given the evidence for an interplay between environmental and genetic factors in esophageal squamous carcinogenesis, the aim of this study was to determine the potential cooperation of the nitrosamine compound N-nitrosomethylbenzylamine (NMBA), an esophageal specific carcinogen, in the cyclin D1 transgenic mice. NMBA was… CONTINUE READING