Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle.

@article{Musgrove1994CyclinDI,
  title={Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle.},
  author={Elizabeth A. Musgrove and Christine S. L. Lee and Michael F. Buckley and Robert Lyndsay Sutherland},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 17},
  pages={8022-6}
}
The sequential transcriptional activation of cyclins, the regulatory subunits of cell-cycle-specific kinases, is thought to regulate progress through the cell cycle. Cyclins are therefore potential oncogenes, and cyclin D1 overexpression and/or amplification at its genomic locus, 11q13, are common features of several human cancers. Induction of cyclin D1 is an early response to mitogenic stimulation in several cell types, but the consequences of altered expression of this gene in human cells of… CONTINUE READING
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